Click on titles for links to fully open access manuscripts

Jaroszynska N, Salzinger A, Tsarouchas TM, Becker CG, Becker T, Lyons DA, MacDonald RB, Keatinge M.
C9ORF72 deficiency results in neurodegeneration in the zebrafish retina
Journal of Neuroscience (2024) 2024 Apr 24:e2128232024. doi: 10.1523/JNEUROSCI.2128-23.2024.

Bin JM, Suminaite D, Benito-Kwiecinski SK, Kegel L, Rubio-Brotons M, Early JJ, Soong D, Livesey MR, Poole RJ, Lyons DA.
Importin 13-dependent axon diameter growth regulates conduction speeds along myelinated CNS axons
Nature Communications (2024) 15(1):1790. doi: 10.1038/s41467-024-45908-6.

Ghosh T, Almeida RG, Zhao C, Mannioui A, Martin E, Fleet A, Chen CZ, Assinck P, Ellams S, Gonzalez GA, Graham SC, Rowitch DH, Stott K, Adams I, Zalc B, Goldman N, Lyons DA, Franklin RJM.
A retroviral link to vertebrate myelination through retrotransposon-RNA-mediated control of myelin gene expression
Cell (2024) 187(4):814-830.e23. doi: 10.1016/j.cell.2024.01.011.

Neely SA, Williamson JM, Klingseisen A, Zoupi L, Early JJ, Williams A, Lyons DA.
New oligodendrocytes exhibit more abundant and accurate myelin regeneration than those that survive demyelination
Nature Neuroscience (2022) 25(4):415-420. doi: 10.1038/s41593-021-01009-x

Vagionitis S, Auer F, Xiao Y, Almeida RG, Lyons DA, Czopka T
Clusters of neuronal neurofascin prefigure the position of a subset of nodes of Ranvier along individual central nervous system axons in vivo
Cell Reports (2022) 38(7):110366. doi: 10.1016/j.celrep.2022.110366.

Almeida RG, Williamson JM, Madden ME, Early JJ, Voas MG, Talbot WS, Bianco IH, Lyons DA.
Myelination induces axonal hotspots of synaptic vesicle fusion that promote sheath growth
Current Biology (2021) doi: 10.1016/j.cub.2021.06.036

Madden ME, Suminaite D, Ortiz E, Early JJ, Koudelka S, Livesey MR, Bianco IH, Granato M, Lyons DA
Central nervous system hypomyelination disrupts axonal conduction and behaviour in larval zebrafish
Journal of Neuroscience( (2021) 41(44):9099-9111

Swire M, Assinck P, McNaughton P, Lyons DA, ffrench-Constant C and Livesey MR
Oligodendrocyte HCN2 channels regulate myelin sheath length
Journal of Neuroscience (2021) JN-RM-2463-20; DOI: https://doi.org/10.1523/JNEUROSCI.2463-20.2021

Moyon S, Frawley R, Marechal D, Huang D, Marshall-Phelps KLH, Kegel L, Bøstrand SMK, Sadowski B, Jiang YH, Lyons DA, Möbius W, Casaccia P.
TET1-mediated DNA hydroxymethylation regulates adult remyelination in mice
Nature Communications (2021) 12(1):3359.doi: 10.1038/s41467-021-23735-3

James OG, Selvaraj BT, Magnani D, Burr K, Connick P, Barton SK, Vasistha NA, Hampton DW, Story D, Smigiel R, Ploski R, Brophy PJ, Ffrench-Constant C, Lyons DA, Chandran S
iPSC-derived myelinoids to study myelin biology of humans
Developmental Cell (2021) 56(9):1346-1358.e6. doi: 10.1016/j.devcel.2021.04.006.

Keatinge M, Tsarouchas TM, Munir T, Porter NJ, Larraz J, Gianni D, Tsai HH, Becker CG, Lyons DA, Becker T.
CRISPR gRNA phenotypic screening in zebrafish reveals pro-regenerative genes in spinal cord injury
PLoS Genetics (2021) 17(4):e1009515. doi: 10.1371/journal.pgen.1009515.

Campbell JS, Davidson AJ, Todd H, Rodrigues FSLM, Elliot AM, Early JJ, Lyons DA, Feng Y, Wood W.
PTPN21/Pez Is a Novel and Evolutionarily Conserved Key Regulator of Inflammation In Vivo
Current Biology (20221) 31(4):875-883.e5. doi: 10.1016/j.cub.2020.11.014.

Klingseisen A, Ristoiu AM, Kegel L, Sherman DL, Rubio-Brotons M, Almeida  RG, Koudelka S, Benito-Kwiecinski SK, Poole RJ, Brophy PJ, Lyons DA.
Oligodendrocyte Neurofascin Independently Regulates Both Myelin Targeting and Sheath Growth in the CNS.
Developmental Cell (2019) 51(6): 730-744

Swire M, Kotelevtsev Y, Webb DJ, Lyons DA, ffrench-Constant C.
Endothelin signalling mediates experience-dependent myelination in the CNS
eLife (2019) doi: 10.7554/eLife.49493

Harty BL, Coelho F, Pease-Raissi SE, Mogha A, Ackerman SD, Herbert AL, Gereau RW 4th, Golden JP, Lyons DA, Chan JR, Monk KR.
Myelinating Schwann cells ensheath multiple axons in the absence of E3 ligase component Fbxw7.
Nature Communications. (2019) Jul 5;10(1):2976. doi: 10.1038/s41467-019-10881-y.

Yang Z, Cole KLH, Qiu Y, Somorjai IML, Wijesinghe P, Nylk J, Cochran S, Spalding GC, Lyons DA, Dholakia K.
Light sheet microscopy with acoustic sample confinement.
Nature Communications. (2019) 10(1):669. doi: 10.1038/s41467-019-08514-5.

Early JJ, Cole KL, Williamson JM, Swire M, Kamadurai H, Muskavitch M, Lyons DA.
An automated high-resolution in vivo screen in zebrafish to identify chemical regulators of myelination.
eLife (2018) pii: e35136. doi: 10.7554/eLife.35136

Almeida RG, Pan S, Cole KLH, Williamson JM, Early JJ, Czopka T, Klingseisen A, Chan JR, Lyons DA.
Myelination of Neuronal Cell bodies when myelin sheaths exceeds axonal demand.
Current Biology (2018) doi: 10.1016/j.cub.2018.02.068.

Baraban M, Koudelka S and Lyons DA.
Ca2+ activity signatures of myelin sheath formation and growth in vivo.
Nature Neuroscience (2018) 21(1):19-23

Karttunen MJ, Czopka T, Goedhart M, Early JJ, Lyons DA.
Regeneration of myelin sheaths of normal length and thickness in the zebrafish CNS correlates with growth of axons in caliber.
PLoS One (2017) 12(5):e0178058.

Redmond SA, Mei F, Eshed-Eisenbach Y, Osso LA, Leshkowitz D, Shen YA, Kay JN, Aurrand-Lions M, Lyons DA, Peles E, Chan JR. 
Somatodendritic Expression of JAM2 Inhibits Oligodendrocyte Myelination.
Neuron (2016) 91(4):824-36

Koudelka S, Voas MG, Almeida RG, Baraban M, Soetaert J, Meyer MP, Talbot WS and Lyons DA.
Individual Neuronal Subtypes Exhibit Diversity in CNS Myelination Mediated by Synaptic Vesicle Release.
Current Biology (2016) 26(11):1447-55

Almeida RG and Lyons DA.
Intersectional Gene Expression in Zebrafish Using the Split KalTA4 System.
Zebrafish (2015) doi:10.1089/zeb.2015.1086

Nawaz S, Sánchez P, Schmitt S, Snaidero N, Mitkovski M, Velte C, Brückner BR, Alexopoulos I, Czopka T, Jung SY, Rhee JS, Janshoff A, Witke W, Schaap IA, Lyons DA, Simons M.
Actin Filament Turnover Drives Leading Edge Growth during Myelin Sheath Formation in the Central Nervous System.
Developmental Cell (2015) 34(2):139-51

Mensch S, Baraban M, Almeida R, Czopka T, Ausborn J, El Manira A, Lyons DA.
Synaptic vesicle release regulates myelin sheath number of individual oligodendrocytes in vivo.
Nature Neuroscience (2015) 18(5):628-30

Snaidero N, Möbius W, Czopka T, Hekking LH, Mathisen C, Verkleij D, Goebbels S, Edgar J, Merkler D, Lyons DA, Nave KA, Simons M.
Myelin Membrane Wrapping of CNS Axons by PI(3,4,5)P3-Dependent Polarized Growth at the Inner Tongue.
Cell. (2014) 156(1-2):277-90.

Czopka, T, ffrench-Constant C, and Lyons DA.
Individual oligodendrocytes have only a few hours in which to generate new myelin sheaths in vivo.
Developmental Cell (2013) 25(6):599-609.

Almeida RG, Czopka, T, ffrench-Constant C, and Lyons DA.
Individual axons regulate the myelinating potential of single oligodendrocytes in vivo.
Development (2011) 138: 4443-4450

Raphael AR, Lyons DA and Talbot WS.
ErbB signaling has a role in radial sorting independent of Schwann cell number.
Glia (2011) 59: 1047-55

Lyons DA, Naylor SG, Scholze, and Talbot WS.
Kif1b is essential for mRNA localization in oligodendrocytes and development of myelinated axons.
Nature Genetics. (2009) 41: 854-858.

Lyons DA, Naylor SG, Mercurio S, Dominguez C, and Talbot WS.
KBP is essential for axonal structure, outgrowth, and maintenance in zebrafish, providing insight into the cellular basis of Goldberg-Shprintzen syndrome.
Development. (2008) 135: 599-608

Tawk M, Araya C, Lyons DA, Reugels AM, Girdler GC, Bayley PR, Hyde DR, Tada M and Clarke JD.
A mirror-symmetric cell division that orchestrates neuroepithelial morphogenesis.
Nature (2007) 446: 797-800

Voas MG, Lyons DA, Naylor SG, Arana N, Rasband MN and Talbot WS.
alphaII-Spectrin Is Essential for Assembly of the Nodes of Ranvier in Myelinated Axons.
Current Biology (2007) 17: 562-8.

Pogoda HM, Sternheim N, Lyons DA, Diamond B, Hawkins TA, Woods IG, Bhatt DH, Franzini-Armstrong C, Dominguez C, Arana N, Jacobs J, Nix R, Fetcho JR,and Talbot WS.
A genetic screen identifies genes essential for development of myelinated axons in zebrafish.
Developmental Biology (2006) 298(1):118-31.

Woods IG, Lyons DA, Voas MG, Pogoda HM and Talbot WS.
nsf is essential for organization of myelinated axons in zebrafish.
Current Biology (2006) 16: 636-48.

Lyons DA, Pogoda HM, Voas MG, Woods IG, Diamond B, Nix R, Arana N, Jacobs J, and Talbot WS.
erbb3 and erbb2 are essential for Schwann cell migration and myelination in zebrafish.
Current Biology (2005) 15: 513-524.

Lyons DA, Guy AT and Clarke JDW.
Monitoring neural progenitor fate through multiple rounds of division in an intact vertebrate brain.
Development (2003) 130: 3427-3436.

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Franklin RJM, Frisén J, Lyons DA
Revisiting remyelination: Towards a consensus on the regeneration of CNS myelin
Seminars in Cell and Developmental Biology (2020) 17;S1084-9521(20)30157-9. doi: 10.1016/j.semcdb.2020.09.009

Suminaite D, Lyons DA, Livesey M.
Myelinated axon physiology and regulation of neural circuit function.
Glia (2019) doi: 10.1002/glia.23665

Williamson JM, Lyons DA.
Myelin Dynamics Throughout Life: An Ever-Changing Landscape?
Front Cell Neurosci. (2018) Nov 19;12:424. doi: 10.3389/fncel.2018.00424.

Allen NJ, Lyons DA
Glia as architects of central nervous system formation and function
Science (2018) 362(6411):181-185

Almeida RG, Lyons DA.
On Myelinated Axon Plasticity and Neuronal Circuit Formation and Function.
Journal of Neuroscience (2017) 37(42):10023-10034.

Cole KLH, Early JJ, Lyons DA.
Drug discovery for remyelination and treatment of MS.
Glia (2017) 65(10):1565-1589.

Klingseisen A, Lyons DA.
Axonal Regulation of Central Nervous System Myelination: Structure and Function
The Neuroscientist (2017) doi: 10.1177/1073858417703030. 

Bin JM and Lyons DA.
Imaging Myelination In Vivo Using Transparent Animal Models
Brain Plasticity (2016)  2(1): 3-29

Almeida RG and Lyons D.
Oligodendrocyte Development in the Absence of Their Target Axons In Vivo.
PLoS ONE (2016) 11(10):e0164432.    

Baraban M, Mensch S, Lyons DA.
Adaptive myelination from fish to man.
Brain Research (2016) 1641(Pt A):149-61.

Almeida RG and Lyons DA
On the resemblance of synapse formation and CNS myelination.
Neuroscience (2014) 276:98-108

Lyons DA and Simons M
Axonal selection and myelin membrane biogenesis in the central nervous system
Current Opinions in Cell Biology (2013) 25(4):512-9

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Lyons DA and Talbot WS
Targeting mechanisms in myelinated axons: not all nodes are created equal.
Developmental Cell (2012) 22:7-9.

Lyons DA and Talbot WS.
Axonal domains: role for paranodal junction in node of Ranvier assembly.
Current Biology (2008) 18:R876-9.

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Kegel L and Lyons DA (Volume editors)
Oligodendrocytes: Methods and Protocols
Methods in Molecular Biology (2019)

Karttunen MJ, and Lyons DA.
A Drug-Inducible Transgenic Zebrafish Model for Myelinating Glial Cell Ablation
Methods Mol Biol. (2019);1936:227-238.

Williamson JM, Lyons DA, and Almeida RG.
Manipulating Neuronal Activity in the Developing Zebrafish Spinal Cord to Investigate Adaptive Myelination.
Methods Mol Biol. (2019);1936:211-225.

Kegel L, Rubio M, Almeida RG, Benito S, Klingseisen A, and Lyons DA.
Forward Genetic Screen Using Zebrafish to Identify New Genes Involved in Myelination.
Methods Mol Biol. (2019);1936:185-209.

Lyons DA and Talbot WS.
Glial Cell development and function in zebrafish.
Cold Spring Harb Perspect Biol. (2014) 7(2):a020586.

Czopka T and Lyons DA.
Dissecting mechanisms of myelinated axon formation using zebrafish.
Methods Cell Biology (2011) 105: 25-62

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