Sarah is a Wellcome Trust Tissue Repair PhD student in the lab. She recently published her first paper.
Newly-made cells repair myelin more efficiently than ones that survive myelin loss
Better understanding remyelination will help us to improve the treatments of myelin diseases, such as MS. We directly compared surviving and newly-made oligodendrocytes in a new zebrafish model of myelin damage, showing that new oligodendrocytes have a much greater capacity for remyelination than survivors. Therefore, our study suggests that the best strategy to promote myelin repair is to boost the production and remyelination capacity of new oligodendrocytes.
Katy Marshall-Phelps, in conversation
Katy is a research fellow and lab manager in the Lyons lab. Her latest paper on NKCC1 in the peripheral nervous system was published in the Journal of Cell Biology on Tuesday.
A newly discovered role of the NKCC1 protein
David Lyons gives his inaugural lecture
On March 2nd, 2020, David Lyons gave his inaugural lecture as Professor of Neurobiology, titled “Brainworks: how are brains formed and how should we treat them”.
The human brain represents the most complex organisation of matter in our known universe. Therefore, understanding how it is formed, how it functions, and how we might treat it remain enormous challenges for the global research community. Given the burden to our society of neurodevelopmental, neurodegenerative, neuropsychiatric and mental health disorders, these challenges need to be addressed.
In his inaugural lecture Professor David Lyons discussed how understanding the fundamental dynamic biological mechanisms and principles that underpin brain formation, function and adaptation provide insights that help us understand its malformation, dysfunction and disease. Professor Lyons showed that it is now possible to directly observe the brain in both health and disease using simple laboratory models. Professor Lyons also explained why his laboratory uses the small transparent zebrafish as a model, and how their work aims to help find treatments for conditions of the nervous system, including multiple sclerosis (MS).
What can zebrafish teach us about myelin repair in MS? | Meet the Researchers (MS Society)
David Lyons presents his research for the MS Society in December 2018.
Professor David Lyons talks to us about all things zebrafish and MS. Why are they so helpful in investigating MS? What can they teach us about myelin repair?...
What do you know about the central nervous system that you didn't know a year ago? | Dave Lyons talks to MS reporters
David Lyons’ interview with Paul from MS reporters in August 2016.