Myelin, made by specialised glial cells, wraps around axons to regulate the speed of electrical transmission throughout our nervous system and to provide metabolic support.

We use genetic screens, chemical screens, sophisticated imaging techniques, and electrophysiology in zebrafish to discover new genes with essential functions in myelinating glial cells, create better animal models of human disorders, and investigate potential novel therapies for diseases of the nervous system such as multiple sclerosis.

We combine our studies in zebrafish with analyses in other model systems, through our wide network of collaborators (see partners).

Please also visit our home at the Centre for Discovery Brain Sciences, University of Edinburgh, and on the Zebrafish Information Network (ZFIN).