Sarah is a Wellcome Trust Tissue Repair PhD student in the lab. She recently published her first paper.
Better understanding remyelination will help us to improve the treatments of myelin diseases, such as MS. We directly compared surviving and newly-made oligodendrocytes in a new zebrafish model of myelin damage, showing that new oligodendrocytes have a much greater capacity for remyelination than survivors. Therefore, our study suggests that the best strategy to promote myelin repair is to boost the production and remyelination capacity of new oligodendrocytes.
Katy is a research fellow and lab manager in the Lyons lab. Her latest paper on NKCC1 in the peripheral nervous system was published in the Journal of Cell Biology on Tuesday.
Our study shows that in the peripheral nervous system, NKCC1 on the myelin and/or the neuron acts to remove excess ions, to maintain normal neuronal activity.
Better understanding remyelination will help us to improve the treatments of myelin diseases, such as MS. We directly compared surviving and newly-made oligodendrocytes in a new zebrafish model of myelin damage, showing that new oligodendrocytes have a much greater capacity for remyelination than survivors. Therefore, our study suggests that the best strategy to promote myelin repair is to boost the production and remyelination capacity of new oligodendrocytes.
